We're ready to go on the official first day of CTIA 2013, and the events kick off with the first of three keynote sessions. It is set to run from 9am to 11am PT, with several industry leaders expected to speak.
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Source: http://feedproxy.google.com/~r/androidcentral/~3/b_r-CQrT2YU/story01.htm
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ZEPHYRHILLS, Fla. (AP) ? Some lucky person walked into a Publix supermarket in suburban Florida over the past few days and bought a ticket now worth an estimated $590.5 million ? the highest Powerball jackpot in history.
But it wasn't Matthew Bogel. On Sunday, he loaded groceries into his car after shopping at the Publix. He shook his head when asked about the jackpot.
"It's crazy, isn't it?" he said. "That's so much money."
It's an amount too high for many to imagine. Compare it to the budget for the city of Zephyrhills: This year's figure is just more than $49 million. The winning Powerball jackpot is 12 times that.
Whoever has the ticket hadn't come forward as of Sunday morning.
"This would be the sixth Florida Powerball winner and right now, it's the sole winner of the largest ever Powerball jackpot," Florida Lottery executive Cindy O'Connell told The Associated Press. "We're delighted right now that we have the sole winner."
Publix spokeswoman Maria Brous said that there are a lot of rumors about who won, but the store doesn't know.
"We're excited for the winner or winners," said Brous. "We don't promote or endorse the lottery, we offer it as a convenience."
O'Connell said Florida has had more Powerball winners than any other state but did not give any indication whether anyone had stepped forward with the winning ticket in Saturday's drawing.
But plenty of people in Zephyrhills ? population 13,337 ? are wondering whether it's someone they know.
Joan Albertson drove over to the Publix early Sunday morning with her camera in hand, just in case the winner emerged. She said she had bought a ticket at a store across the street, and the idea of winning that much money was still something of a shock.
"Oh, there's so much good that you could do with that amount of money." Albertson said. "I don't even know where to begin.
Zephyrhills is a small city in Pasco County, about 30 miles northeast of downtown Tampa. Once a rural farming town, it's now known as a hotbed for skydiving activity, and the home to large retiree mobile home parks and Zephyrhills bottled water.
And now, one lucky lottery ticket.
"I'm getting text messages and messages from Facebook going, 'uh, did you win the lottery?'" Sandra Lewis said. "No, I didn't win, guys. Sorry."
Sara Jeltis said her parents in Michigan texted her with the news Sunday morning.
"Well, it didn't click till I came here," she said, gesturing to the half-dozen TV live trucks humming in the Publix parking lot. "And I'm like, wow I can't believe it, it's shocking! Out of the whole country, this Publix, in little Zephyrhills would be the winner."
A call to Publix's headquarters in Lakeland, Fla., was not immediately returned Sunday.
With four out of every five possible combinations of Powerball numbers in play, lottery executives said Saturday that someone was almost certain to win the game's highest jackpot, a windfall of hundreds of millions of dollars ? and that's after taxes.
The winning numbers were 10, 13, 14, 22 and 52, with a Powerball of 11.
Estimates had earlier put the jackpot at around $600 million. But Powerball's online site said Sunday that the jackpot had reached an estimated $590.5 million.
The world's largest jackpot was a $656 million Mega Millions jackpot in March 2012.
Terry Rich, CEO of the Iowa Lottery, initially confirmed that one Florida winning ticket had been sold. He told AP that following the Florida winner, the Powerball grand prize was being reset at an estimated jackpot of $40 million, or about $25.1 million cash value.
The chances of winning the prize were astronomically low: 1 in 175.2 million. That's how many different ways you can combine the numbers when you play. But lottery officials estimated that about 80 percent of those possible combinations had been purchased recently.
While the odds are low for any one individual or individuals, O'Connell said, the chance that one hits paydirt is what makes Powerball exciting.
"There is just the chance that you will have the opportunity, and Florida is a huge Powerball state," O'Connell said. "We have had more winners than any other state that participates in Powerball."
The longshot odds didn't deter people across Powerball-playing states ? 43 plus Washington, D.C., and the U.S. Virgin Islands ? from lining up at gas stations and convenience stores Saturday.
Clyde Barrow, a public policy professor at the University of Massachusetts-Dartmouth, specializes in the gaming industry. He said one of the key factors behind the ticket-buying frenzy is the size of the jackpot ? people are interested in the easy investment.
"Even though the odds are very low, the investment is very small," he said. "Two dollars gets you a chance."
Lewis, who went to the Publix on Sunday to buy water, said she didn't play ? and she isn't upset about it.
"Life goes on," she said, shrugging. "I'm good."
___
Rodriguez reported from Des Moines, Iowa.
___
Follow Barbara Rodriguez at http://twitter.com/bcrodriguez.
Source: http://news.yahoo.com/small-fla-city-wonders-won-powerball-jackpot-163342761.html
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Actress Julianne Moore arrives for the opening ceremony and the screening of The Great Gatsby at the 66th international film festival, in Cannes, southern France, Wednesday, May 15, 2013. (Photo by Joel Ryan/Invision/AP)
Actress Julianne Moore arrives for the opening ceremony and the screening of The Great Gatsby at the 66th international film festival, in Cannes, southern France, Wednesday, May 15, 2013. (Photo by Joel Ryan/Invision/AP)
Actress Julianne Moore arrives for the opening ceremony and the screening of The Great Gatsby at the 66th international film festival, in Cannes, southern France, Wednesday, May 15, 2013. (Photo by Joel Ryan/Invision/AP)
CANNES, France (AP) ? Julianne Moore sometimes identifies with the characters she plays but when it came to playing a bad mother in "What Maisie Knew," she couldn't relate.
In the recently released film, Moore portrays a rock-star mom going through a bitter divorce who's having trouble connecting to her 6-year-old daughter, Maisie.
The role couldn't have been farther from her heart. Moore, who has a 15-year-old son and 11-year-old daughter, said motherhood was something that came easily for her and a role she always craved since she was a little girl.
"I thought, 'I don't know if I will get married, but I do want to have children,'" Moore said in an interview on the opening day of the Cannes Film Festival. "I said, 'I'm going to have a boy and a girl.' You know, all those ridiculous fantasies that you have when you're 10 years old ? for me, the fact that that came true, it's kind of unbelievable."
It's partly because of her devotion to her family that her time in Cannes was decidedly brief. She arrived Monday and was due to leave Thursday in time to see her son play guitar in his school jazz band and to be home for another event involving her daughter.
"I don't go away for long periods of time," she explained.
But the other reason for her short stay was because she wasn't in Cannes to promote a movie at all. Neither "What Maisie Knew" nor her other new film, "The English Teacher," was featured in the festival.
Instead, Moore is one of several L'Oreal spokeswomen brought in by the cosmetics company for the festival; others include actresses Freida Pinto, in Cannes this week, and Eva Longoria, set to arrive later.
"In a weird kind of way, there might even be more pressure on the red carpet because you're representing a beauty brand," Moore said, laughing. "But it's fun."
At 52, Moore takes special pride being a spokeswoman for a cosmetics company, given the focus on youth in modern culture.
"Somebody asked me yesterday if I felt like I had some kind of mission for women. I wouldn't say that, but I feel like I can represent women who are my age," she said. "I can say to my friends, look, we exist. Here we are."
And as she gets older, the actress, who won both an Emmy and a Golden Globe for her portrayal of Sarah Palin in last year's "Game Change," said what worries her doesn't involve her looks anyway.
"Mostly I worry about it being over quickly, my life," she said.
"We talk about aging and getting older and blah, blah, blah. What does that really mean? And what it really means, particularly as you are in middle age, is that you have less of your life in front of you than you have behind you, and that in itself is anxiety producing,'" she added.
Moore noted that one of the main benefits of youth was being totally unaware of the passage of time.
"That's what they talk about, about the blessing of being young, you don't have that feeling. You feel like it's forever," she said. "(But) there's a certain point in your life where you're like, 'Oh. . it's not.'"
That's when "you want to make sure that you're living the life that you want to live and with the people you want to be with," she said.
___
Follow Nekesa Mumbi Moody on Twitter at http://www.twitter.com/nekesamumbi
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May 16, 2013 ? Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of genome sequencing, an enormous debate has erupted over whether patients' rights will continue in an era of medical genomics.
Recent recommendations from the American College of Medical Genetics and Genomics (ACMG) suggest no. On March 22, the ACMG released recommendations stating that when clinical sequencing is undertaken for any medical reason, laboratories must examine 57 other specific genes to look for incidental findings. These findings must then be reported to the clinician and the patient. In an April 25 "clarification," ACMG said that failure to report these findings would be considered "unethical." The patient has no opportunity to opt-out of the testing of the 57 genes, except to decline all sequencing. The recommendations also apply to children.
In a paper to be published in 'Science 'May 16 online ahead of print, authors Susan M. Wolf, J.D. (University of Minnesota), George J. Annas, J.D., M.P.H. (Boston University), and Sherman Elias, M.D. (Northwestern University) push back against these recommendations, and offer compelling reasons why patient autonomy must remain firmly in place as science advances. Their article on Patient Autonomy and Incidental Findings in Clinical Genomics urges ACMG to reconsider their recommendations. This article is published with a reply by Amy McGuire, J.D., Ph.D. (Baylor College of Medicine) and colleagues.
Wolf, Annas, and Elias argue that, "The ACMG's 'minimum list [of 57 genes]' includes mutations in genes that patients have long been able to refuse testing for, including cancer risk mutations (such as BRCA1) and cardiovascular risk mutations." They point out that "There are many circumstances in which a patient may decline such testing and information, even if the results could open avenues for intervention. The patient may already be battling another disease, such as advanced cancer, or be late in life and see more burden than benefit in added genetic information. The patient may also fear that 'extra' results in their medical record will invite risk of discrimination."
ACMG says that applying these recommendations to children may help adult family members understand their own health risks. However, Wolf et al. point out that "this is exactly what past recommendations have rightly rejected, in limiting genetic testing and disclosure of genetic information to what is medically necessary during childhood." The authors cite long-standing policy discouraging childhood testing for adult-onset conditions. "Delaying testing and return of genetic information not medically useful in childhood allows the child to reach adulthood and then make a choice based on his or her own values."
The ACMG indicates that their list of genes to test without consent will grow. Their report says that laboratories may look for variants in other genes, "as deemed appropriate," and that ACMG will review the roster of 57 genes annually. Wolf et al. voice concern that "As the list expands, so will the scope of testing without consent?." The authors urge the importance of patients' rights, especially in an era of genome sequencing when extensive genetic information can be generated on any patient.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/H43SuU2_zq4/130516142545.htm
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Public release date: 15-May-2013
Share ] Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Hot on the TRAIL of graft vs. host disease
For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD). In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. Immune cells engineered to express higher levels of TRAIL killed the cells that cause GVHD and increased anti-tumor activity. In an accompanying commentary, Nelson Chao suggests that new therapeutics may take advantage of TRAIL-expressing cells to promote an anti-tumor response without putting patients at risk for GVHD.
TITLE: Fratricidal TRAIL+T cells suppress GVHD and augment anti-tumor activity after bone marrow transplantation
AUTHOR CONTACT:
Arnab Ghosh
Memorial Sloan-Kettering Cancer Center, New York, , USA
Phone: 646-888-2317; E-mail: ghosha1@mskcc.org
View this article at: http://www.jci.org/articles/view/66301?key=66e50de3cd0d7e99a4d8
ACCOMPANYING COMMENTARY
TITLE: Blazing a new TRAIL in hematopoietic cell transplantation
AUTHOR CONTACT:
Nelson J. Chao
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1011; Fax: 919-668-1091; E-mail: chao0002@mc.duke.edu
View this article at: http://www.jci.org/articles/view/69909?key=43f0101604c8f6bb12da
Researchers identify signals that direct the immune system to reject a transplanted organ
Organ transplant rejection occurs when the transplant recipient's immune system identifies the transplanted organ as foreign tissue and attacks it. It was previously thought that T cells, the immune cells that mediate rejection, must first be activated by molecules known as chemokines in order to migrate to the transplanted organ. In this issue of the Journal of Clinical Investigation, Fadi Lakkis and colleagues at the University of Pittsburgh used mice to demonstrate that chemokine stimulation of T cells is not required for migration. Instead, these cells must come into contact with immune-stimulating proteins (antigens) that are specifically expressed by the transplanted organ. In an accompanying commentary, Terry Strom discusses how these findings could have important implications for the design of novel anti-rejection therapeutics.
TITLE: Cognate antigen directs CD8+ T cell migration to vascularized transplants
AUTHOR CONTACT:
Fadi G. Lakkis
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Phone: 412 383-5774; Fax: 412-383-9990; E-mail: lakkisf@upmc.edu
View this article at: http://www.jci.org/articles/view/66722?key=5debbc8dd29fc8e22b12
ACCOMPANYING COMMENTARY
TITLE: Transplant rejection and paradigms lost
AUTHOR CONTACT:
Terry Strom
Beth Israel Deaconess Medical Center, Boston, MA, USA
Phone: 1-617-735-2880; Fax: 1 617 667-0923; E-mail: tstrom@bidmc.harvard.edu
View this article at: http://www.jci.org/articles/view/69385?key=ee127335912183bcc713
ALSO IN THIS ISSUE
TITLE: Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
AUTHOR CONTACT:
George Kollias
Biomedical Sciences Research Centre (BSRC) "Alexander FLEMING", Institute o, Vari, GRC
Phone: 00302109656507; E-mail: kollias@fleming.gr
View this article at: http://www.jci.org/articles/view/65624?key=95dcd1ab2462f49889fd
TITLE: Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model
AUTHOR CONTACT:
Ying-Hui Fu
University of California San Francisco, San Francisco, CA, USA
Phone: 415-502-5614; E-mail: Ying-hui.fu@ucsf.edu
View this article at: http://www.jci.org/articles/view/66737?key=16236a3ef2fb14130105
TITLE: PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
AUTHOR CONTACT:
Rafi Ahmed
Emory University, Atlanta, GA, USA
Phone: 404-727-3571; E-mail: rahmed@emory.edu
View this article at: http://www.jci.org/articles/view/67008?key=331ea19f479943e34a83
TITLE: The genomic landscape of small intestine neuroendocrine tumors
AUTHOR CONTACT:
Andreas Beutler
Mayo Clinic Rochester, Rochester, MN, USA
Phone: 507 2848009; E-mail: beutler.andreas@mayo.edu
View this article at: http://www.jci.org/articles/view/67963?key=946338907594d6d91dfd
TITLE: Specific peripheral B cell tolerance defects in patients with multiple sclerosis
AUTHOR CONTACT:
Eric Meffre
Yale University School of Medicine, New Haven, CT, USA
Phone: 1-203-737-4535; Fax: 1-203-785-7903; E-mail: eric.meffre@yale.edu
View this article at: http://www.jci.org/articles/view/68775?key=e407c6c0d214181b9fad
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 15-May-2013 Share ] Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Hot on the TRAIL of graft vs. host disease
For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD). In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. Immune cells engineered to express higher levels of TRAIL killed the cells that cause GVHD and increased anti-tumor activity. In an accompanying commentary, Nelson Chao suggests that new therapeutics may take advantage of TRAIL-expressing cells to promote an anti-tumor response without putting patients at risk for GVHD.
TITLE: Fratricidal TRAIL+T cells suppress GVHD and augment anti-tumor activity after bone marrow transplantation
AUTHOR CONTACT:
Arnab Ghosh
Memorial Sloan-Kettering Cancer Center, New York, , USA
Phone: 646-888-2317; E-mail: ghosha1@mskcc.org
View this article at: http://www.jci.org/articles/view/66301?key=66e50de3cd0d7e99a4d8
ACCOMPANYING COMMENTARY
TITLE: Blazing a new TRAIL in hematopoietic cell transplantation
AUTHOR CONTACT:
Nelson J. Chao
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1011; Fax: 919-668-1091; E-mail: chao0002@mc.duke.edu
View this article at: http://www.jci.org/articles/view/69909?key=43f0101604c8f6bb12da
Researchers identify signals that direct the immune system to reject a transplanted organ
Organ transplant rejection occurs when the transplant recipient's immune system identifies the transplanted organ as foreign tissue and attacks it. It was previously thought that T cells, the immune cells that mediate rejection, must first be activated by molecules known as chemokines in order to migrate to the transplanted organ. In this issue of the Journal of Clinical Investigation, Fadi Lakkis and colleagues at the University of Pittsburgh used mice to demonstrate that chemokine stimulation of T cells is not required for migration. Instead, these cells must come into contact with immune-stimulating proteins (antigens) that are specifically expressed by the transplanted organ. In an accompanying commentary, Terry Strom discusses how these findings could have important implications for the design of novel anti-rejection therapeutics.
TITLE: Cognate antigen directs CD8+ T cell migration to vascularized transplants
AUTHOR CONTACT:
Fadi G. Lakkis
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Phone: 412 383-5774; Fax: 412-383-9990; E-mail: lakkisf@upmc.edu
View this article at: http://www.jci.org/articles/view/66722?key=5debbc8dd29fc8e22b12
ACCOMPANYING COMMENTARY
TITLE: Transplant rejection and paradigms lost
AUTHOR CONTACT:
Terry Strom
Beth Israel Deaconess Medical Center, Boston, MA, USA
Phone: 1-617-735-2880; Fax: 1 617 667-0923; E-mail: tstrom@bidmc.harvard.edu
View this article at: http://www.jci.org/articles/view/69385?key=ee127335912183bcc713
ALSO IN THIS ISSUE
TITLE: Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
AUTHOR CONTACT:
George Kollias
Biomedical Sciences Research Centre (BSRC) "Alexander FLEMING", Institute o, Vari, GRC
Phone: 00302109656507; E-mail: kollias@fleming.gr
View this article at: http://www.jci.org/articles/view/65624?key=95dcd1ab2462f49889fd
TITLE: Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model
AUTHOR CONTACT:
Ying-Hui Fu
University of California San Francisco, San Francisco, CA, USA
Phone: 415-502-5614; E-mail: Ying-hui.fu@ucsf.edu
View this article at: http://www.jci.org/articles/view/66737?key=16236a3ef2fb14130105
TITLE: PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
AUTHOR CONTACT:
Rafi Ahmed
Emory University, Atlanta, GA, USA
Phone: 404-727-3571; E-mail: rahmed@emory.edu
View this article at: http://www.jci.org/articles/view/67008?key=331ea19f479943e34a83
TITLE: The genomic landscape of small intestine neuroendocrine tumors
AUTHOR CONTACT:
Andreas Beutler
Mayo Clinic Rochester, Rochester, MN, USA
Phone: 507 2848009; E-mail: beutler.andreas@mayo.edu
View this article at: http://www.jci.org/articles/view/67963?key=946338907594d6d91dfd
TITLE: Specific peripheral B cell tolerance defects in patients with multiple sclerosis
AUTHOR CONTACT:
Eric Meffre
Yale University School of Medicine, New Haven, CT, USA
Phone: 1-203-737-4535; Fax: 1-203-785-7903; E-mail: eric.meffre@yale.edu
View this article at: http://www.jci.org/articles/view/68775?key=e407c6c0d214181b9fad
###
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/joci-jet050813.php
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Realty
Somluck Srimalee
The Nation May 15, 2013 1:00 am
The property market in Greater Bangkok will grow by 7-8 per cent this year to a value between Bt330 billion and Bt350 billion, leading developer Pruksa Real Estate estimates.
Last year the nationwide property market was valued at Bt626 billion, Bt314 billion in the provinces and the rest in Bangkok and its suburbs.
In the first quarter of this year, the Greater Bangkok market recorded sales worth Bt88.39 billion, down 0.4 per cent from the same period last year. In terms of volume, however, the metropolitan market increased 2 per cent year on year to 32,371 units.
Most listed property firms reported improved revenue in the first quarter of this year, and some of them, such as Pruksa and LPN Development, showed strong growth in net profit. Others enjoyed lower profits, while Sansiri saw a loss.
Pruksa reported presales worth Bt12.32 billion generating total revenue of Bt6.34 billion and net profit of Bt773 million in the first quarter, up 117 per cent, 36 per cent and 22 per cent respectively from the same period of 2012.
Land and Houses announced revenue of Bt5.9 billion in the first quarter, up 25 per cent year on year, while net profit of Bt1.4 billion reflected a drop of 6 per cent.
Sansiri recorded presales worth Bt21 billion for total revenue of Bt5.18 billion and a net loss of Bt86.43 million in the first quarter. The company reported to the Stock Exchange of Thailand that the loss was due to higher marketing costs.
Raimon Land posted a net profit of Bt142 million for the first quarter, compared with a net loss of Bt70 million in the same quarter of 2012.
Ananda Development recorded a net loss of Bt83 million in the first quarter compared with a net loss of Bt202 million in the same period of last year. But the company's consolidated account recorded a net profit of Bt4.87 million in the quarter, turning around a net loss of Bt258.20 million in the first three months of last year.
Lalin Property Development recorded revenue of Bt623 million and net profit of Bt117.65 million in the first quarter, up 94.7 per cent and 185 per cent respectively year on year.
LPN Development reported revenue of Bt2.4 billion and net profit of Bt360.07 million, up 14 per cent and 22 per cent respectively from the first quarter of 2012.
Property Perfect announced revenue of Bt2.45 billion, up 31 per cent year on year, and net profit of Bt116.5 million, down 7.3 per cent.
Pruksa Real Estate president and chief executive officer Thongma Vijitpongpun said that despite the Bank of Thailand's warning about a bubble developing in the property sector, the market still was driven more by real demand than speculation. Demand is especially strong for low-rise homes including townhouses and detached and semi-detached houses.
However, he accepted that condominiums may have experienced speculation in some locations, and said developers were being careful to investigate the market before deciding to expand projects.
Pruksa director and chief business officer Prasert Taedullayasatit said: "In those locations that show oversupply, most property firms have delayed launching new projects. This is why the value of new residential-project launches in the first quarter dropped from the same period last year while demand in terms of volume has continued to grow."
However, he believes that the total property market will continue to grow by 7-8 per cent this year in both Bangkok and the provinces. As a result, the company is sticking with its plan to launch 78 projects worth Bt55 billion this year, including the 19 worth Bt22.49 billion launched in the first quarter. Pruksa is also maintaining its targets of Bt35.4 billion in presales and total revenue of Bt33 billion for 2013.
Meanwhile, the company's investment plan overseas has continued, and is now in the process of transferring Bt336 million worth of its Bt796-million residential project in Bangalore, India, in the first quarter. It plans to launch its first project in Vietnam in the second half of the year, Thongma said.
The company may also expand into Indonesia this year or next, he said.
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When my sons were growing up, I dreaded meeting with their teachers. I was always a tiny bit afraid that somewhere in the middle of the conversation the teacher would lean forward, grab my ear, and chastise me. This may be an irrational fear, but it is deeply seeded. It was planted many years ago at St. Agnes elementary school, and it was nurtured in middle school and high school by just about every teacher who had the misfortune of having me in his or her class.
Despite my less-than-stellar early education, I went on to graduate college magna cum laude. I earned a master?s degree, and stopped just short of my dissertation for a Ph.D. I?ve written and published more than a dozen books ? including three best-sellers ? won awards for writing, and have used the skills I learned in school to help build several multimillion-dollar businesses.
All that said, because of my deeply seeded irrational fear, I had a negative idea of what I could accomplish early in my business career.
But that didn?t stop me.
In ?The Power of Positive Thinking,? Norman Vincent Peale says that unless you have a positive attitude about yourself and your abilities, ?you cannot be successful or happy.?
I believe he is half right.
Yes, you need a positive attitude to be happy. But you can be quite successful by most conventional measurements simply by applying my success formula with persistence:
My own experience proves that, by doing this, you can achieve almost anything you want in life ? even if you don?t have much faith in your own abilities. And it has been proven to me dozens of times over by others ? people I?ve known personally, people I?ve heard about from friends and colleagues, and even people I?ve read about.
But what if you want happiness? Or what if, in fact, happiness and equanimity are integral to your definition of success? Well, then you need to follow Peale?s advice and start thinking positive thoughts about yourself.
Lack of self-confidence, Peale said, ?is one of the great problems besetting people today.? He makes reference to a survey of college students indicating that for 75 percent of them, confidence was the thing most lacking in their life.
Who could argue with that? If you?ve ever choked up in an interview, forgotten your lines in a play, blown a free throw, or been verbally stifled by a rude comment, you know too well the effect that a lack of self-confidence has on performance.
?The blows of life, the accumulation of difficulties, the multiplication of problems tend to sap energy and leave you spent and discouraged,? Peale says. In such situations, ?it is easy to lose track of your abilities and powers? ? but by re-appraising your personal assets, you can convince yourself that ?you are less defeated than you think you are.?
As an example, Peale tells how he counseled a 52-year-old man who came to him ?in great despondency.? Everything in his life, the man said, had been ?swept away? by a recent business setback. ?Everything I built up over a lifetime is gone.?
Peale recognized that although the man had indeed experienced a serious setback, his chief problem was the way he viewed it.
?Suppose we take a piece of paper and write down the values you have left,? he suggested. And so they did. Among other things, the list included these personal assets:
That?s not a bad list. And, if you?re feeling down, I would hope that focusing on positive personal assets like these could help you overcome the worst feelings you could possibly have about yourself.
Let me tell you a story?
About 20 years ago, I became friendly with a man, about my own age, who had all of the above mentioned assets ? plus a very successful printing business, plus a significant personal fortune. He was a very charismatic guy ? always good-natured, upbeat, full of good fun, and easy to like. Then, one day, his business collapsed. I don?t remember the details but, suddenly, he was bankrupt.
I heard about it soon after it happened. When I called to console him, it was too late. Sobbing, his wife told me that he had killed himself.
I couldn?t understand why he did it. He had had so many other things going for him that, in my eyes, his business and the wealth it produced was just gravy. Apparently, he didn?t see it that way.
If my friend had read Peale?s advice ? and had taken it to heart ? he?d be alive today and enjoying all the wonderful things he had, including the love of his wife, children, and friends. He?d also, I?m quite sure, have made back all the money he lost, plus plenty more.
[Ed. Note: Mark Morgan Ford was the creator of Early To Rise. In 2011, Mark retired from ETR and now writes the Palm Beach Letter. His advice, in our opinion, continues to get better and better with every essay, particularly in the controversial ones we have shared today. We encourage you to read everything you can that has been written by Mark.]
The Truth About Positive Thinking,Source: http://www.earlytorise.com/the-truth-about-positive-thinking/
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May 13, 2013 ? Mice that exercise in running wheels exhibit increased neurogenesis in the brain. Crucial to this process is serotonin signaling. These are the findings of a study by Dr. Friederike Klempin, Daniel Beis and Dr. Natalia Alenina from the research group led by Professor Michael Bader at the Max Delbr?ck Center (MDC) Berlin-Buch. Surprisingly, mice lacking brain serotonin due to a genetic mutation exhibited normal baseline neurogenesis. However, in these serotonin-deficient mice, activity-induced proliferation was impaired, and wheel running did not induce increased generation of new neurons.
Scientists have known for some time that exercise induces neurogenesis in a specific brain region, the hippocampus. However, until this study, the underlying mechanism was not fully understood. The hippocampus plays an important role in learning and in memory and is one of the brain regions where new neurons are generated throughout life.
Serotonin facilitates precursor cell maturation
The researchers demonstrated that mice with the ability to produce serotonin are likely to release more of this hormone during exercise, which in turn increases cell proliferation of precursor cells in the hippocampus. Furthermore, serotonin seems to facilitate the transition of stem to progenitor cells that become neurons in the adult mouse brain.
For Dr. Klempin and Dr. Alenina it was surprising that normal baseline neurogenesis occurs in mice that, due to a genetic mutation, cannot produce serotonin in the brain. However, they noted that some of the stem cells in serotonin-deficient mice either die or fail to become neurons.
Yet, these animals seem to have a mechanism that allows compensation for the deficit, in that progenitor cells, an intermediate stage in the development from a stem cell to a neuron, divide more frequently. According to the researchers, this is to maintain the pool of these cells.
However, the group of wheel-running mice that do not produce serotonin did not exhibit an exercise-induced increase in neurogenesis. The compensatory mechanism failed following running. The researchers concluded: "Serotonin is not necessarily required for baseline generation of new neurons in the adult brain, but is essential for exercise-induced hippocampal neurogenesis."
Hope for new approaches to treat depression and memory loss in the elderly
Deficiency in serotonin, popularly known as the "molecule of happiness," has been considered in the context of theories linking major depression to declining neurogenesis in the adult brain. "Our findings could potentially help to develop new approaches to prevent and treat depression as well as age-related decline in learning and memory," said Dr. Klempin and Dr. Alenina.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/9_P1ODMUwOQ/130513110926.htm
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New spot gives us more insight into Crowe's role as Superman's dad, Jor-El.
By Todd Gilchrist
Source: http://www.mtv.com/news/articles/1707194/man-of-steel-russell-crowe-uk-ad.jhtml
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TEL AVIV (Reuters) - Facebook Inc is in advanced talks to acquire Israeli mobile satellite navigation start-up Waze for $800 million to $1 billion, business daily Calcalist reported on Thursday.
Due diligence is underway after a term sheet was signed, Calcalist said, adding that talks began six months ago.
Waze uses satellite signals from members' smartphones to generate maps and traffic data, which it then shares with other users, offering real-time traffic info.
Officials at Waze declined to comment on the report.
Waze and Facebook partnered in October 2012 when Waze released its updated version that allows users to share their drive with their Facebook friends.
This would be Facebook's third acquisition in Israel. It bought Snaptu in 2011 for $70 million and Face.com in 2012 for $60 million.
In the last year, Waze tripled its user base to 45 million and in March alone, 1.5 million users downloaded the free mobile navigation app, Calcalist said.
(Reporting by Tova Cohen; Editing by David Cowell)
Source: http://www.businessinsider.com/facebook-close-to-buying-waze-for-1-billion-2013-5
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President Barack Obama turns around and pauses before entering his car at Austin Bergstrom International Airport, Thursday, May 9, 2013, in Austin, Texas. Obama visited Austin to give talks on technology development and the economy at Manor New Tech High School and Applied Materials. (AP Photo/Marisa Vasquez, The Daily Texan)
President Barack Obama turns around and pauses before entering his car at Austin Bergstrom International Airport, Thursday, May 9, 2013, in Austin, Texas. Obama visited Austin to give talks on technology development and the economy at Manor New Tech High School and Applied Materials. (AP Photo/Marisa Vasquez, The Daily Texan)
President Barack Obama tours Applied Materials Inc., with Rick Gesing, left, Mike Splinter, center, and Mary Humiston, right, during a visit to the facilities in Austin, Texas, Thursday, May 9, 2013. (AP Photo/Austin American-Statesman, Rodolfo Gonzalez, Pool)
WASHINGTON (AP) ? President Barack Obama is launching a new effort to rally the public around his hotly disputed health care law, a strategy aimed at shoring up key components of the sweeping federal overhaul and staving off yet another challenge from Republicans.
The president will specifically target women and young people, groups that backed him overwhelmingly during his presidential campaigns. During a Mother's Day-themed event at the White House on Friday, Obama will promote the benefits of the law for women, including free cancer screenings and contraceptives, and ask moms to urge their uninsured adult children to sign up for the health insurance "exchanges" that open this fall.
The exchanges are the centerpiece of the landmark overhaul of the nation's health insurance system. Three years after it became law, the measure widely known as "Obamacare" remains controversial, with GOP lawmakers resolving anew to overturn it and many Americans unsure how they'll be affected.
White House advisers acknowledge they struggled in explaining the complex law to the public when it passed in 2010. Now, with the final components being implemented, Obama allies see a fresh opportunity to sell the American people on the merits of measures that will be central to the president's legacy.
"We're in the phase for the actual meat of the law to come online," said Neera Tanden of the Center for American Progress, a liberal group aligned with the White House. "It's important for the public to recognize that the law has tangible benefits to people so they feel comfortable enrolling."
Beginning Oct. 1, consumers can enroll in coverage through health insurance marketplaces called "exchanges" established by the states or the federal government. Coverage under the private plans begins Jan. 1, and nearly 30 million uninsured Americans are eventually expected to take part.
But in order to keep insurance premiums down, young, healthy people will have to join up in order to counteract the costs from seniors and others with health problems.
The uncertainty surrounding the exchanges has many Democrats nervous, including retiring Sen. Max Baucus, D-Mont., one of the architects of the overhaul. He said last month that the health care law is heading for a "train wreck" because of a bumbling implementation.
The president conceded last week that there would be "glitches and bumps" as the final phases of the health care law ? formally the Affordable Health Care Act ? are rolled out. But he said most people will be unaffected by the changes that are still to come.
"For the 85 to 90 percent of Americans who already have health insurance, this thing has already happened," Obama said. "Their only impact is that their insurance is stronger, better, more secure than it was before. Full stop. That's it. They don't have to worry about anything else."
Many Republicans strongly disagree, saying the full impact of the law will ripple throughout the economy. House Republicans announced this week that they planned to hold a vote on repealing the overhaul ? the 37th time the House has voted to repeal all of part of the law. The Democratic-controlled Senate has ignored those votes each time.
House Speaker John Boehner, R-Ohio, acknowledged that the move was largely political, noting that there were 70 new members of the House this year who haven't had an opportunity to register a vote against the health law. As for why Republicans are intent on repealing the law rather than trying to amend its pieces, Boehner said, "I don't believe there is a way to fix this and make it acceptable to the American people."
Administration officials insist it's bad politics for Republicans to keep pressing for repeal. They say the American people don't want to harp on old issues, and cite the law's popularity among young people, blacks, Hispanics and women ? all demographic groups the GOP has struggled to attract in recent elections.
"It just demonstrates again how out of touch with what the American people want the House Republicans have become," White House spokesman Jay Carney said Thursday.
In reality, a massive number of people are actually uninformed about the provisions of the law. A new poll from the Kaiser Family Foundation showed more than 4 in 10 Americans didn't know the Affordable Health Care Act was still law or was being implemented. About half feel they don't have enough information about the law to know how it will affect them.
Under the law, virtually all Americans must carry health insurance starting next year, although most will just keep the coverage they now have through their jobs, Medicare or Medicaid.
___
Follow Julie Pace at http://twitter.com/jpaceDC
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BEIRUT: Hezbollah leader Sayyed Hasan Nasrallah said Thursday Syria would supply his party with ?game-changing? weapons in response to last week?s Israeli airstrikes on Damascus that reportedly targeted shipments of sophisticated Iranian arms destined for the group.
In a fiery televised speech devoted mostly to responding to the Israeli air raids in Syria, Nasrallah said Hezbollah would assist other resistance groups seeking to liberate the Syrian Golan Heights from Israeli occupation.
His remarks are bound to heighten tensions in the already volatile region, especially after he clearly hinted that the advanced weapons his party would receive from Syria could upset the balance of power with Israel.
Nasrallah said the Israeli airstrikes were aimed at achieving two objectives: neutralizing Syria in the decades-long Arab-Israeli conflict, and preventing Hezbollah from further bolstering its arsenal, which includes thousands of long-range missiles that can hit any target in Israel, according to the Hezbollah leader.
Following the Israeli attacks in Damascus, Nasrallah said, Syria would provide Hezbollah with advanced weapons which it has not had before.?Syria?s first response to Israel?s airstrikes was to tell Israel that if your goal was to prevent the capabilities of the resistance [Hezbollah] from growing, then take note ... [Syria] will provide the resistance with sophisticated weapons that the resistance has never had before,? Nasrallah said, speaking through a giant screen via a video link. ?We mean game-changing.?
?Syria?s second strategic response is to open the Golan front and to open the door to popular resistance in the Golan,? he said, drawing cheers from the crowd.
?The third response is to prepare rocket launch pads and give orders for firing missiles without returning to the command. This has frightened the Israelis who sent messages to calm the situation,? he added.
Nasrallah was addressing a Hezbollah rally south of Beirut marking the 25th anniversary of the establishment of the party?s Al-Nour radio station.
He said his group was ready to use such strategic weapons in its fight against Israel. ?We, the Lebanese resistance, are ready to receive any kind of game-changing weapons, even if it upsets the balance of power [with Israel]. ... We deserve such weapons, and we will use them to defend our people and our country.?
?Just as Syria stood by the Lebanese people and gave moral and financial backing to its people?s resistance, we announce that we stand by the side of the Syrian popular resistance,? Nasrallah said. He pledged ?moral, financial and logistical support, cooperation and coordination and for the liberation of the Syrian Golan? which was captured by Israel in the 1967 War.
Israel carried out two airstrikes near Damascus on May 5, bringing the total number to three this year. Western media, quoting Israeli sources, said the warplanes targeted advanced Iranian-made guided missiles bound for Hezbollah, while the Syrian government said the air raid hit a military and scientific research center near Damascus and caused casualties.
Israel has repeatedly warned that it won?t allow war-torn Syria to transfer advanced weaponry to Hezbollah, saying this would cross a red line. It has voiced concern that Syria?s stockpile of sophisticated weaponry could fall in the hands of Hezbollah and other anti-Israel militant groups.
Nasrallah denied media reports that 300 Syrian soldiers were killed in the airstrikes. ?According to my information only three or four martyrs from the Syrian military were killed,? he said.
Nasrallah said the Israeli air raids were aimed at removing Syria from the equation of the Arab-Israeli conflict. He added that Syria and its strategic ally, Iran, were the main sources of strength of the region?s resistance movements.
?Everyone knows how much Syria has given to the Palestinian and Lebanese resistance? against Israel, Nasrallah said. ?In all of Arab history, no other Arab regime has given us as much as President Bashar Assad?s regime has.?
Nasrallah, a staunch supporter of Assad, has acknowledged his party?s involvement in the Syrian fighting, saying Hezbollah fighters were helping Lebanese Shiites living in Syrian towns near the border with Lebanon defend themselves against rebel attacks.
Nasrallah, who hinted last week that Syria?s allies, Iran and Russia, would intervene militarily to prevent the fall of the regime, praised Assad?s approach to deal with the Israeli attacks.
?Everything that is happening today indicates that Syria has a strong leadership that is managing the battles with the [Israeli] enemy in a wise, calm and courageous manner that will achieve victory in the future, God willing,? he said.
While he reiterated that the only solution to the crisis in Syria was through a compromise between the regime and the opposition, Nasrallah slammed Arab countries for not acting to end the 26-month-long bloody conflict.
?It?s shameful the U.S. is the one seeking Syria?s interests while the Arabs seem to be the ones destroying Syria, which is something serving the enemy?s interests.?
On domestic issues, Nasrallah reiterated his party?s demand that the next government be made up of political parties according to their size in Parliament.
?Given the domestic and regional circumstances ... there should be a government of true national partnership ... and national unity rather than a government of challenge,? he added.
Nasrallah also reiterated that his party?s lawmakers would vote for the Orthodox Gathering?s electoral proposal if it is put up for a vote during next week?s Parliament session. ?Hezbollah will vote for the Orthodox Gathering?s draft law because we have already given our word on that and we were clear,? he said. ? Additional reporting by Dana Khraiche and Thomas El-Basha
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May 9, 2013 ? Different brain areas are activated when we choose to suppress an emotion, compared to when we are instructed to inhibit an emotion, according a new study from the UCL Institute of Cognitive Neuroscience and Ghent University.
In this study, published in Brain Structure and Function, the researchers scanned the brains of healthy participants and found that key brain systems were activated when choosing for oneself to suppress an emotion. They had previously linked this brain area to deciding to inhibit movement.
"This result shows that emotional self-control involves a quite different brain system from simply being told how to respond emotionally," said lead author Dr Simone Kuhn (Ghent University).
In most previous studies, participants were instructed to feel or inhibit an emotional response. However, in everyday life we are rarely told to suppress our emotions, and usually have to decide ourselves whether to feel or control our emotions.
In this new study the researchers showed fifteen healthy women unpleasant or frightening pictures. The participants were given a choice to feel the emotion elicited by the image, or alternatively to inhibit the emotion, by distancing themselves through an act of self-control.
The researchers used functional magnetic resonance imaging (fMRI) to scan the brains of the participants. They compared this brain activity to another experiment where the participants were instructed to feel or inhibit their emotions, rather than choose for themselves.
Different parts of the brain were activated in the two situations. When participants decided for themselves to inhibit negative emotions, the scientists found activation in the dorso-medial prefrontal area of the brain. They had previously linked this brain area to deciding to inhibit movement.
In contrast, when participants were instructed by the experimenter to inhibit the emotion, a second, more lateral area was activated.
"We think controlling one's emotions and controlling one's behaviour involve overlapping mechanisms," said Dr Kuhn.
"We should distinguish between voluntary and instructed control of emotions, in the same way as we can distinguish between making up our own mind about what do, versus following instructions."
Regulating emotions is part of our daily life, and is important for our mental health. For example, many people have to conquer fear of speaking in public, while some professionals such as health-care workers and firemen have to maintain an emotional distance from unpleasant or distressing scenes that occur in their jobs.
Professor Patrick Haggard (UCL Institute of Cognitive Neuroscience) co-author of the paper said the brain mechanism identified in this study could be a potential target for therapies.
"The ability to manage one's own emotions is affected in many mental health conditions, so identifying this mechanism opens interesting possibilities for future research.
"Most studies of emotion processing in the brain simply assume that people passively receive emotional stimuli, and automatically feel the corresponding emotion. In contrast, the area we have identified may contribute to some individuals' ability to rise above particular emotional situations.
"This kind of self-control mechanism may have positive aspects, for example making people less vulnerable to excessive emotion. But altered function of this brain area could also potentially lead to difficulties in responding appropriately to emotional situations."
Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/2DYRq7na970/130509104354.htm
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A new class of drug targeting skin cancer's genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases.
The research involves the drug Dz13, a targeted molecular therapy, which was developed at the University of New South Wales (UNSW) and has now been found to be safe in a clinical trial of patients with the common skin cancer, basal-cell carcinoma.
"This is the first report of a drug of this type to be used in humans," says UNSW Medicine's Professor Levon Khachigian, who has been developing the DNAzyme technology for 10 years.
"It's a smart drug, which targets a bad protein that controls tumour growth and spread," says Professor Khachigian, the Director of the UNSW Centre for Vascular Research. The collaborative trial was conducted by researchers from UNSW, the University of Sydney and Royal Prince Alfred Hospital.
The findings have been published today in the prestigious journal The Lancet.
"Even though we were only testing for safety, there were unexpected positive effects," says Professor Khachigian.
"The drug knocked down levels of this bad protein and the tumours shrunk in the majority of patients."
The researchers hope subsequent trials will prove that larger doses of the drug over a longer time period will be more effective.
"Targeted molecular therapy like this might also offer novel, effective, and less invasive therapeutic options for basal-cell carcinoma," says Professor Gary Halliday, from the University of Sydney, who is one of the co-authors of the study.
If the next stages of the clinical trials in basal-cell carcinoma are successful, the researchers hope that within three years, the drug could be used as a treatment for these cancers, reducing scarring and the costs and inconvenience associated with surgery.
Basal-cell carcinoma is the most common cancer among fair-skinned people worldwide with Australia having the highest incidence.
"This may be a 'one-size fits all' therapy, because it targets a master regulator gene called c-Jun which appears to be involved in a range of diseases," says Professor Khachigian, who predicts that melanoma and eye diseases including macular degeneration and diabetic retinopathy are the likely future targets for research.
A phase one trial in skin melanoma is expected to begin in a month.
###
University of New South Wales: http://www.unsw.edu.au
Thanks to University of New South Wales for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/128154/New_class_of_drug_targets_skin_cancer
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While Dish Network's $25.5 billion bid for Sprint continues to wave in the breeze, the company has reported its earnings for the first quarter. Net subscriber growth only totaled 36,000 compared to 104,000 in the same period last year, as subscriber churn rose due to a price hike earlier this year. Its profits were lower in Q1 2013 than 2012 partially due to Blockbuster-related drops and a boost received last year from its DBSD purchase. (We're guessing higher content costs for things like AMC didn't help either.) A growing percentage of the 654,000 new customers it added got Hopper DVRs, which also raised costs a bit for the new set-top boxes and all those TV advertisements its been running. Even as it waits to add some terrestrial LTE to its "Seinfeld" wireless data strategy, the dishNET satellite broadband service added 66,000 customers in the quarter, up from from just 6,000 new customers in Q1 2012. We'll have to wait for the earnings call at noon to see if CEO Charlie Ergen has anything else to say about its battle with Softbank to buy Sprint, but all of the data is in the press release and slide below.
Filed under: Home Entertainment, HD
Source: Dish Network Q1 2013 investor summary (PDF), Q1 Earnings
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Two NASA space telescopes have captured what appears to be the most powerful star explosion ever detected, a cosmic event so luminous that scientists dubbed it 'eye-wateringly bright' despite being 3.6 billion light-years from Earth.
The Swift space telescope caught sight of the most powerful star explosion ever recorded.
Stefan Immler / Swift / NASA
EnlargeTwo NASA space telescopes have captured what appears to be the most powerful star explosion ever detected, a cosmic event so luminous that scientists dubbed it "eye-wateringly bright" despite being 3.6 billion light-years from Earth.
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On April 27, NASA's Swift Space Telescope and the Fermi Gamma-ray Space Telescope spotted the highest-energy gamma-ray burst (GRB) ? an explosion of a massive star in the last stage of its life ? ever before seen.
NASA scientists combined the observations into a video animation of the historic gamma-ray burst to illustrate the surprising brightness of this star explosion.
"We have waited a long time for a gamma-ray burst this shockingly, eye-wateringly bright," Julie McEnery, a project scientist for the Fermi Gamma-ray Space Telescope at NASA's Goddard Space Flight Center in Greenbelt, Md., said in a statement. "The GRB lasted so long that a record number of telescopes on the ground were able to catch it while space-based observations were still ongoing."
One of the gamma-rays emitted during the eruption ? seen in the constellation Leo ? was three times more energetic than any other gamma-ray burst recorded by Fermi's Large Area Telescope (LAT), the instrument on the spacecraft responsible for detecting these kinds of explosions.
The gamma-ray burst (named GRB 130427A) was also the longest ever recorded, NASA officials said.
"The GeV [energy] emission from the burst lasted for hours, and it remained detectable by the LAT for the better part of a day, setting a new record for the longest gamma-ray emission from a GRB," NASA officials added.
Gamma-ray bursts are the brightest explosions yet observed in the universe.
"Astronomers think most [gamma-ray bursts] occur when massive stars run out of nuclear fuel and collapse under their own weight," NASA officials said in a statement. "As the core collapses into a black hole, jets of material shoot outward at nearly the speed of light."
Swift's detection of this burst was delayed. The satellite was moving between cosmic targets at the time of the eruption, but the spacecraft captured the explosion less than a minute after it began. Swift also aided astronomers in placing the gamma-ray burst closer to Earth than most other star explosions of its kind, NASA officials said.
"This GRB is in the closest 5 percent of bursts, so the big push now is to find an emerging supernova, which accompanies nearly all long GRBs at this distance," Goddard's Neil Gehrels, principal investigator for Swift, said in a statement.
Scientists are hoping to find a supernova within the area of the explosion in order to trace the gamma-ray burst back to its origins.
Observatories on the ground are keeping an eye on GRB 130427A's area of the sky to locate the supernova by mid-May.
Follow Miriam Kramer on Twitter and Google+. Follow us on Twitter, Facebookand Google+. Original article on SPACE.com.
Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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May 6, 2013 ? Chemicals called polybrominated diphenyl ethers (PBDEs) have been used for decades to reduce fires in everyday products such as baby strollers, carpeting and electronics. A new study to be presented on Monday, May 6, at the Pediatric Academic Societies (PAS) annual meeting shows that prenatal exposure to the flame retardants is associated with lower intelligence and hyperactivity in early childhood.
"In animal studies, PBDEs can disrupt thyroid hormone and cause hyperactivity and learning problems," said lead author Aimin Chen, MD, PhD, assistant professor in the Department of Environmental Health at University of Cincinnati College of Medicine. "Our study adds to several other human studies to highlight the need to reduce exposure to PBDEs in pregnant women."
Dr. Chen and his colleagues collected blood samples from 309 pregnant women enrolled in a study at Cincinnati Children's Hospital Medical Center to measure PBDE levels. They also performed intelligence and behavior tests on the women's children annually until they were 5 years old.
"We found maternal exposure to PBDEs, a group of brominated flame retardants mostly withdrawn from the U.S. market in 2004, was associated with deficits in child cognition at age 5 years and hyperactivity at ages 2-5 years," Dr. Chen said. A 10-fold increase in maternal PBDEs was associated with about a 4 point IQ deficit in 5-year-old children.
Even though PBDEs, except Deca-BDEs, are not used as a flame retardant in the United States anymore, they are found on many consumer products bought several years ago. In addition, the chemicals are not easily biodegradable, so they remain in human tissues and are transferred to the developing fetus.
"Because PBDEs exist in the home and office environment as they are contained in old furniture, carpet pads, foams and electronics, the study raises further concern about their toxicity in developing children," Dr. Chen concluded.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
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BASRA, Iraq (AP) ? The fighter's body was collected at an Iraqi border crossing with Iran, then carried on Monday through the streets of this southern city as mourners hailed his sacrifice in protecting a revered shrine in Syria.
Diaa Mutashar al-Issawi was one of several Shiite fighters from Iraq who have trickled into Syria for months, providing a measure of support for Syrian regime forces battling mainly Sunni rebels. They are drawn by a sense of religious duty to ensure the sanctity of the revered Sayida Zeinab shrine outside the Syrian capital of Damascus as sectarian divisions harden in Syria's 2-year-old civil war.
Al-Issawi is not the first Iraqi Shiite fighter thought to have died in Syria. But Iran's alleged role in repatriating his body strengthens suggestions that Tehran is involved in coordinating the movement of foreign fighters to aid its embattled ally, Syria. Iran is a key backer of Syrian President Bashar Assad's regime, and the United States suspects Tehran is using Iraqi airspace to shuttle weapons to Syria.
Iraq remains officially neutral in the Syrian conflict, and officials had no comment on the return of al-Issawi's body.
But the Shiite-led government in Baghdad fears Assad's ouster would lead to the rise of a conservative Sunni government in Syria. That could fuel renewed Sunni-Shiite strife in Iraq, where sectarian violence is on the rise. Assad's Alawite sect is a branch of Shiite Islam.
"It was a religious and ethical duty to go to Syria and defend our holy shrines," said an Iraqi Shiite fighter from Basra who referred to himself only by the nickname Abu Zeinab, fearing reprisals. "Martyr Diaa and I fought together ... to foil the Takfiris' attacks," he said, using the term for a radical ideology that urges Sunni Muslims to kill anyone they consider an infidel.
Journalists in the southern oil hub of Basra saw al-Issawi's coffin ? similar to the those Iran once used to repatriate the dead during the Iran-Iraq War ? leaving atop a vehicle from the Iraqi side of the Shalamcha border crossing with Iran. Masked men at the scene insisted photographers not take pictures as a convoy of around 20 cars departed.
Iranian officials could not be reached for comment.
At a funeral procession later in the morning, police blocked roads as dozens of tribesmen and Shiite clerics carried the coffin through the streets.
Some in the crowd vowed to make a similar sacrifice and chanted slogans against the Sunni-dominated Free Syrian Army rebel group and the al-Qaida-affiliated Jabhat al-Nusra, which in the past year has become the most effective fighting force within the opposition trying to topple Assad.
Iraqi Shiites who make the journey to Syria say their aim is to defend the Zeinab shrine, which marks what is believed to be the grave of the granddaughter of the Prophet Muhammad. A placard held aloft among the mourners called al-Issawi a "happy martyr" who died in the grounds of the holy site.
Syria has several sites revered by Shiites, and the war has sparked fears that Sunni extremists, many of whom consider such shrines heretical, could attack them. The 2006 bombing of a shrine in Iraq came close to plunging the country into civil war.
Al-Issawi was killed in a mortar attack during the past two days, according to Ali Falih Madhi, a prominent member of the Hezbollah Brigades in Basra who is widely known by his nom de guerre Abu Mujahid al-Maliki.
He said the fighter joined the group's Lord of the Martyrs Brigades early this year and left for Syria a month ago. Al-Issawi's body was transported from Syria via Iran before being returned to Iraq, he said.
"It is not possible to send back the bodies of the martyrs by land in eastern Syria to Iraq because the fighters of the Free Syrian Army control the area," Madhi said.
A Hezbollah Brigades official last month confirmed that one of its fighters, Afrad Mohsen al-Hemedawi, died defending a Shiite holy shrine in Syria.
The Iraqi Hezbollah is independent of the better-known Lebanese Shiite militant group of the same name. Both receive backing from Iran.
Syrian rebels accuse the Lebanese Hezbollah of fighting alongside Assad's troops and attacking rebels from inside Lebanese territory. Iraqi Shiites have gotten less attention so far.
It is difficult to say how many Iraqi fighters have made their way to Syria. Iraqi officials insist they are not involved and do not know how many of their citizens are fighting across the border.
"If there are Iraqi fighters in Syria, then they went on their own," said Ali al-Moussawi, a spokesman for Iraq's prime minister. "Our position is clear. The Iraqi government is not part of this."
A Western diplomat, who was not authorized to speak publicly and insisted of anonymity, said there are indications of Iraqi Shiites playing a role in Syria. He said their activities are not just around Sayyida Zeinab, which he said is used as a "rallying banner" to encourage recruits.
Aram Nerguizian, a Middle East expert at the Center for Strategic and International Studies in Washington, said Iraqi and Lebanese Shiites form "an important rear guard" for Syria's Assad as his own forces try to make advances against the rebels. "I'd be frankly surprised if you didn't see an uptick" in the number of Iraqi fighters, he said.
Nerguizian said Iraqi Shiite fighters traveling to Syria are certainly coordinating with Iran to some extent, though it is unclear how much Tehran is calling the shots.
One area of coordination might be in providing transport, since flying Shiite fighters to Syria out of Baghdad might damage Iraq's international standing and expose it to greater American pressure.
"If you have Iraqi Shia going by land to Iran and then on to Syria, that creates a zone of ambiguity," Nerguizian said.
Elsewhere in Iraq on Monday, a pair of car bombs in the Baghdad suburb of Hussainya and another explosion at a restaurant in the southern neighborhood of Dora in the Iraqi capital killed at least 10 people. Also, attackers in a speeding car threw grenades at Sunni worshippers leaving al-Ihsan mosque in Baghdad's Mansour neighborhood, killing seven and wounding 16 others. The casualties were confirmed by police and hospital officials, who spoke on condition of anonymity because they were not authorized to release the details.
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Schreck reported from Baghdad. AP writers Sinan Salaheddin and Sameer N. Yacoub in Baghdad contributed.
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Follow Adam Schreck on Twitter at http://twitter.com/adamschreck
Source: http://news.yahoo.com/iraqi-death-hints-irans-role-syrian-crisis-205346727.html
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